Schizencephaly

Schizencephaly is a development disorder characterized by abnormal rives in the cerebral hemispheres (NINDS publication). Some scientists deem it to be a slightly severe, yet restricted, of the cortical malformations (Volpe, 1995). The pathology of this disorder shows that the crack may be narrow or closed or wide and open. The cleft is commonly located near the precentral or postcentral gyri, they can be unilateral (occurring on only one side) or bilaterally symmetrical (occurring on twain sides). Multiple small convolutions in the kinky brain, or polymicrogyria, have been noted. Other malformations included or usually noted with this disorder are microcephaly (small brain), gray result heterotopia (absence of binocular equilibrium in the eyes), dysplasia (abnormal tissue development) and hypoplasia (tissue underdevelopment) (Carson, 1996). It has been deemed a cephalic disorder (by NINDS), congenital neurologic malformation (Icenogle & Kaplan, 1981), or a neuronal migration disorder (Volpe, 1995). All are accurate and basically describe some specific characteristics of the disorder. As in both discussion of a neurologic disorder, the discussion of its onset is frigid in defining it. There is believed to be a flak agenesis of a portion of the germinative zones and thereby the cerebral groyne that leaves the seams or clefts in this anatomical abnormality. This injury in the germinative zones is as well deemed to affect the migrating neurons-therefore the notion of neuronal migration disorder. Migrational events in the cerebrum gather in the third month of gestation. For a better understanding, a brief discussion of ontogenesis-the summons of predetermined events occurring in comme il faut sequence to insure normal development of the CNS-is in order. pattern ontogenesis of neural tissue is a complex bear upon that can be divided into three developmental phases: (1) embryogenesis from 0 to 1 month o f gestation characterized by induction; (2) ! cellular...If you wish to get a full essay, order it on our website: OrderEssay.net

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